Rolandi E, Santaniello B, Bagnasco M, Cataldi A, Garibaldi C, Franceschini R, Barreca T
Department of Internal Medicine, University of Genoa, Italy.
Acta Endocrinol (Copenh). 1992 Jul;127(1):23-6. doi: 10.1530/acta.0.1270023.
Plasma atrial natriuretic hormone (ANH) values were evaluated in 28 hyperthyroid patients and in 11 hypothyroid patients and compared with 20 healthy subjects. In hyperthyroid patients plasma ANH basal levels were significantly (p less than 0.01) higher (14.2 +/- 1.6 pmol/l) than in controls (7.8 +/- 0.4 pmol/l) and in hypothyroid patients (6.4 +/- 0.3 pmol/l). No significant differences were found between controls and hypothyroid patients. The propranolol-induced decrease in heart rate in hyperthyroid patients did not significantly affect the plasma ANH values. Conversely, after the methimazole-induced euthyroidism a return within the normal range of ANH values was observed. The thyroxine replacement in hypothyroid patients determined a small but significant (p less than 0.05) increase in plasma ANH values. Observed data suggest that in humans thyroid hormones may influence plasma ANH concentrations independently of their effect on heart rate.
对28例甲状腺功能亢进患者和11例甲状腺功能减退患者的血浆心房利钠激素（ANH）值进行了评估，并与20名健康受试者进行了比较。甲状腺功能亢进患者的血浆ANH基础水平（14.2±1.6 pmol/L）显著高于对照组（7.8±0.4 pmol/L）和甲状腺功能减退患者（6.4±0.3 pmol/L）（p<0.01）。对照组和甲状腺功能减退患者之间未发现显著差异。甲状腺功能亢进患者中普萘洛尔引起的心率下降并未显著影响血浆ANH值。相反，在甲巯咪唑诱导甲状腺功能正常后，观察到ANH值恢复到正常范围。甲状腺功能减退患者的甲状腺素替代治疗导致血浆ANH值有小幅但显著的升高（p<0.05）。观察到的数据表明，在人类中，甲状腺激素可能独立于其对心率的影响而影响血浆ANH浓度。
