Holland D B, Gowland G, Cunliffe W J
Acta Derm Venereol. 1985;65(6):551-3.
Sub-populations of leucocytes, complement C3, CRP, alpha 2 macroglobulin and immunoglobulin levels were measured in the peripheral blood of 28 (14 male, 14 female) normal control subjects and 108 (53 male, 55 female) acne patients. Significantly increased levels of inflammatory mediators were found much earlier in female than in male acne patients. The female defence system would seem to be more competent at responding to the acne assault; may account for the milder forms of acne found in young women; and have relevance both in treatment and the design and interpretation of clinical trials.
在28名（14名男性，14名女性）正常对照受试者和108名（53名男性，55名女性）痤疮患者的外周血中，检测了白细胞亚群、补体C3、C反应蛋白、α2巨球蛋白和免疫球蛋白水平。发现女性痤疮患者炎症介质水平显著升高的时间比男性早得多。女性的防御系统似乎在应对痤疮攻击方面更有能力；这可能解释了年轻女性中痤疮症状较轻的原因；并且在治疗以及临床试验的设计和解释方面都具有相关性。
