CHAKRABARTI R, FEARNLEY G R
J Clin Pathol. 1962 May;15(3):228-30. doi: 10.1136/jcp.15.3.228.
Natural or spontaneous fibrinolytic activity of the blood is due to a labile activator which is stabilized by fibrin formation. Current methods of measuring spontaneous fibrinolysis require either low temperature centrifugation when plasma is used or photography when diluted whole blood is used and neither is available in the average laboratory. A method of measuring fibrinolytic activity in blood, the ;fibrinolytic potential', which requires only simple apparatus, is described. It is found to correlate well with the dilute blood clot lysis time, and should be of value for investigating the hitherto neglected problem of spontaneous fibrinolytic activity in occlusive vascular disease.
血液的天然或自发纤维蛋白溶解活性归因于一种不稳定的激活剂，这种激活剂会因纤维蛋白的形成而稳定下来。目前测量自发纤维蛋白溶解的方法，若使用血浆则需要低温离心，若使用稀释全血则需要摄影，而普通实验室都无法做到。本文描述了一种测量血液中纤维蛋白溶解活性的方法，即“纤维蛋白溶解潜力”，该方法仅需简单设备。研究发现它与稀释血液凝块溶解时间密切相关，对于研究闭塞性血管疾病中迄今被忽视的自发纤维蛋白溶解活性问题应具有重要价值。
