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健康与血管疾病状态下的血液及血管壁纤溶活性

Blood and vein-wall fibrinolytic activity in health and vascular disease.

作者信息

Browse N L, Gray L, Jarrett P E, Morland M

出版信息

Br Med J. 1977 Feb 19;1(6059):478-81. doi: 10.1136/bmj.1.6059.478.

Abstract

The resting blood fibrinolytic activity of 120 normal subjects and 294 patients with various forms of vascular disease was assessed by measuring the dilute blood clot lysis time and fibrin plate lysis area before and after 10 minutes of venous congestion. The tissue fibrinolytic activity of several of these subjects was assessed in vein biopsy specimens. The results suggested that there was a correlation between blood and tissue fibrinolytic activity and that certain venous diseases, particularly recurrent superficial thrombophlebitis and venous liposclerosis, were associated with a deficiency of blood and tissue fibrinolytic activity.

摘要

通过测量静脉充血10分钟前后的稀释血凝块溶解时间和纤维蛋白平板溶解面积,评估了120名正常受试者和294名患有各种血管疾病患者的静息血纤维蛋白溶解活性。对其中一些受试者的静脉活检标本进行了组织纤维蛋白溶解活性评估。结果表明,血液和组织纤维蛋白溶解活性之间存在相关性,并且某些静脉疾病,特别是复发性浅表血栓性静脉炎和静脉脂肪硬化,与血液和组织纤维蛋白溶解活性不足有关。

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