Sumimoto T, Hamada M, Ohtani T, Suzuki M, Abe M, Matsuoka H, Fujiwara Y, Sekiya M, Hiwada K
Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
Cardiovasc Drugs Ther. 1992 Aug;6(4):425-8. doi: 10.1007/BF00054192.
Left ventricular diastolic function before and after the administration of disopyramide (100 mg) or diltiazem (30 mg) was assessed in 10 patients with nonobstructive type hypertrophic cardiomyopathy. Left ventricular diastolic function was assessed by Doppler echocardiography. The peak early (E) and late (A) diastolic flow velocities and E/A ratio (E/A) were measured. Three hours after the administration of disopyramide, blood pressure did not significantly change, but heart rate was decreased significantly (p less than 0.01). Disopyramide increased the E velocity and E/A ratio from 43.8 +/- 15.0 cm/sec to 51.3 +/- 16.1 cm/sec and from 0.71 +/- 0.20 to 1.00 +/- 0.24 (each p less than 0.01), respectively, and decreased the A velocity from 63.9 +/- 18.5 cm/sec to 52.1 +/- 14.9 cm/sec (p less than 0.01). Diltiazem increased the E velocity and E/A ratio from 42.8 +/- 12.5 cm/sec to 46.4 +/- 13.4 cm/sec (p less than 0.05) and from 0.74 +/- 0.21 to 0.96 +/- 0.28 (p less than 0.01), respectively, and decreased the A velocity from 60.6 +/- 16.4 cm/sec to 50.2 +/- 15.6 cm/sec (p less than 0.01). These results indicate that disopyramide improved left ventricular diastolic filling in hypertrophic cardiomyopathy, and its effect was similar to that of diltiazem.
在10例非梗阻型肥厚型心肌病患者中评估了丙吡胺（100毫克）或地尔硫䓬（30毫克）给药前后的左心室舒张功能。通过多普勒超声心动图评估左心室舒张功能。测量舒张早期（E）和晚期（A）血流峰值速度以及E/A比值（E/A）。丙吡胺给药三小时后，血压无显著变化，但心率显著降低（p<0.01）。丙吡胺使E速度和E/A比值分别从43.8±15.0厘米/秒增加到51.3±16.1厘米/秒以及从0.71±0.20增加到1.00±0.24（各p<0.01），并使A速度从63.9±18.5厘米/秒降低到52.1±14.9厘米/秒（p<0.01）。地尔硫䓬使E速度和E/A比值分别从42.8±12.5厘米/秒增加到46.4±13.4厘米/秒（p<0.05）以及从0.74±0.21增加到0.96±0.28（p<0.01），并使A速度从60.6±16.4厘米/秒降低到50.2±15.6厘米/秒（p<0.01）。这些结果表明丙吡胺改善了肥厚型心肌病患者的左心室舒张充盈，其效果与地尔硫䓬相似。
