Douma S, Zamboulis C, Karagiannis A, Sinakos Z
2nd Propedeutic Department of Internal Medicine, Aristotelian University of Thessaloniki Medical School, Ippokration General Hospital, Greece.
Nouv Rev Fr Hematol (1978). 1992;34(1):73-8.
Adrenaline was infused in incremental doses of 0.05 up to 0.1 microgram/kg/min over a 60-min period in nine patients with mild essential hypertension and six age-matched normotensive controls. Blood samples were drawn at preset time intervals and plasma adrenaline, platelet count, serum thromboxane B2 (TxB2) and plasma beta-thromboglobulin (beta-TG) were measured. Adrenaline levels (m +/- SEM) rose significantly, from 0.078 +/- 0.01 (baseline) to 0.902 +/- 0.03 ng/ml (60 min), in the hypertensive group; a similar increase was observed in the control group (from 0.049 +/- 0.007 to 0.877 +/- 0.03 ng/ml). Platelet count increased significantly at early time points and remained high throughout infusion in both groups (hypertensive from 250 +/- 25 to 305 +/- 24 x 10(3)/microliters, control from 219 +/- 16 to 260 +/- 18 x 10(3)/microliters). TxB2 levels likewise increased significantly from 15 minutes after initiation of infusion. In hypertensive subjects the mean resting value of 186 +/- 17 ng/ml rose to 312 +/- 42 ng/ml, while in control subjects the resting value of 174 +/- 29 ng/ml rose to 286 +/- 32 ng/ml. Baseline levels of TxB2 were found to be higher in the hypertensive patients but not significantly. beta-TG levels increased from an initial value of 43.84 +/- 3.69 ng/ml to 59.5 +/- 4.69 ng/ml at 60 min in the hypertensive group, while a similar change from 28.7 +/- 19.2 ng/ml to 40.36 +/- 3.16 ng/ml was observed in the control group. These changes were significant, as was the difference between basal values in the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
对9例轻度原发性高血压患者和6例年龄匹配的血压正常对照者，在60分钟内以0.05至0.1微克/千克/分钟的递增剂量静脉输注肾上腺素。按预设时间间隔采集血样，测定血浆肾上腺素、血小板计数、血清血栓素B2（TxB2）和血浆β-血小板球蛋白（β-TG）。高血压组肾上腺素水平（m±SEM）显著升高，从0.078±0.01（基线）升至0.902±0.03纳克/毫升（60分钟）；对照组也观察到类似升高（从0.049±0.007升至0.877±0.03纳克/毫升）。两组血小板计数在输注早期均显著增加，并在整个输注过程中保持高位（高血压组从250±25升至305±24×10³/微升，对照组从219±16升至260±18×10³/微升）。TxB2水平同样在输注开始15分钟后显著升高。高血压受试者的平均静息值从186±17纳克/毫升升至312±42纳克/毫升，而对照组静息值从174±29纳克/毫升升至286±32纳克/毫升。发现高血压患者TxB2的基线水平较高，但无显著差异。高血压组β-TG水平从初始值43.84±3.69纳克/毫升在60分钟时升至59.5±4.69纳克/毫升，而对照组观察到类似变化，从28.7±19.2纳克/毫升升至40.36±3.16纳克/毫升。这些变化具有显著性，两组基础值之间的差异也具有显著性。（摘要截选至250字）
