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肺大疱疾病的外科治疗。

Surgery for bullous disease of the lung.

作者信息

Vigneswaran W T, Townsend E R, Fountain S W

机构信息

Harefield Hospital, Uxbridge, UK.

出版信息

Eur J Cardiothorac Surg. 1992;6(8):427-30. doi: 10.1016/1010-7940(92)90067-8.

DOI:10.1016/1010-7940(92)90067-8
PMID:1389249
Abstract

Between July 1986 and December 1990, 22 patients underwent 23 operative procedures for bullous disease at Harefield Hospital. Their ages ranged from 21 to 71 years (mean 49.8 years). There were 18 males and 4 females. All patients were operated upon for symptoms of exertional dyspnoea. Four patients belonged to functional class IV, 11 to class III and 3 to class II. In 80% of patients, computed tomography was performed as part of the preoperative assessment. The bullae were dealt with in 13 patients on the right side, in 7 on the left and in 2 bilaterally. Six patients were treated by a modified Monaldi procedure and 17 by bullectomy. There was no operative mortality. Mean hospital stay was 14.8 days. Two patients required a second operative procedure during their hospital stay for persistent air leak and pneumothorax. One of these had a Monaldi procedure in the first instance but underwent bullectomy later. All patients improved symptomatically, 10 patients moving up two grades and 12, one grade. Mean FEV1, FVC and MVV were significantly improved postoperatively, but there were no significant changes in RV or TLC. A graduated exercise test was performed in 4 patients. Improvements were seen in ventilation and oxygen consumption at anaerobic threshold and maximum exercise. Surgery for bullous disease improves symptoms by reducing airway obstruction and increasing ventilatory capacity on exercise.

摘要

1986年7月至1990年12月期间,22例患者在 Harefield 医院接受了23次针对大疱性疾病的手术。他们的年龄在21岁至71岁之间(平均49.8岁)。其中男性18例,女性4例。所有患者均因劳力性呼吸困难症状接受手术。4例患者属于功能IV级,11例属于III级,3例属于II级。80%的患者在术前评估时进行了计算机断层扫描。13例患者右侧有大疱,7例左侧有大疱,2例双侧有大疱。6例患者接受了改良的莫纳尔迪手术,17例接受了肺大疱切除术。无手术死亡病例。平均住院天数为14.8天。2例患者在住院期间因持续漏气和气胸需要进行第二次手术。其中1例最初接受了莫纳尔迪手术,但后来接受了肺大疱切除术。所有患者症状均有改善,10例患者功能等级提升两级,12例患者提升一级。术后平均第一秒用力呼气容积(FEV1)、用力肺活量(FVC)和最大通气量(MVV)均显著改善,但残气量(RV)或肺总量(TLC)无显著变化。4例患者进行了分级运动试验。在无氧阈值和最大运动时,通气和氧消耗均有改善。大疱性疾病手术通过减轻气道阻塞和增加运动时的通气能力改善症状。

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