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采用β-环糊精手性固定相高效液相色谱法拆分特非那定对映体

Resolution of terfenadine enantiomers by beta-cyclodextrin chiral stationary phase high-performance liquid chromatography.

作者信息

Weems H, Zamani K

机构信息

Department of Pharmacology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, Maryland 20814-4799.

出版信息

Chirality. 1992;4(4):268-72. doi: 10.1002/chir.530040411.

DOI:10.1002/chir.530040411
PMID:1389964
Abstract

Enantiomers of terfenadine were resolved by high-performance liquid chromatography (HPLC) using a chiral stationary phase (CSP) column packed with beta-cyclodextrin (beta-CD) covalently bound to silica. Separation was achieved in both the reverse phase and normal phase modes. Resolution of enantiomers was confirmed by ultraviolet-visible absorption, circular dichroism, and mass spectral analysis.

摘要

采用高效液相色谱法（HPLC），使用填充有与硅胶共价结合的β-环糊精（β-CD）的手性固定相（CSP）柱，拆分特非那定的对映体。在反相和正相模式下均实现了分离。通过紫外可见吸收、圆二色性和质谱分析确证了对映体的拆分。

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