采用含β-环糊精型手性固定相的高效液相色谱法对d-/l-去甲肾上腺素和肾上腺素进行对映体分离。
Enantiomeric separation of d-/l-norepinephrine and -epinephrine by high-performance liquid chromatography with a beta-cyclodextrin type chiral stationary phase.
作者信息
Fukushima T, Murayama K, Santa T, Homma H, Imai K
机构信息
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
出版信息
Biomed Chromatogr. 1998 Jan-Feb;12(1):1-3. doi: 10.1002/(SICI)1099-0801(199801/02)12:1<1::AID-BMC694>3.0.CO;2-W.
Abstract
Enantiomeric separation of d-/l-norepinephrine (NE) and d-/l-epinephrine (E) was investigated with various mobile phases by high-performance liquid chromatography using a beta-cyclodextrin type chiral stationary phase as a chiral column. The mobile phase of 2.5 M phosphate buffer (pH 3.0) gave separation factors (alpha s) of 1.04 and 1.06 for NE and E, respectively.
摘要
使用β-环糊精型手性固定相作为手性柱，通过高效液相色谱法，采用不同流动相研究了d-/l-去甲肾上腺素（NE）和d-/l-肾上腺素（E）的对映体分离。2.5M磷酸盐缓冲液（pH 3.0）流动相下，NE和E的分离因子（αs）分别为1.04和1.06。
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