Goldring J D, Molyneux M E, Taylor T, Wirima J, Hommel M
Department of Tropical Medicine and Infectious Diseases, Liverpool School of Tropical Medicine.
Br J Haematol. 1992 Jul;81(3):413-8. doi: 10.1111/j.1365-2141.1992.tb08249.x.
We observed considerable diversity in the cytoadherence of Plasmodium falciparum isolates from Malawi to melanoma cells, U937 cells and human peripheral monocytes. Each isolate exhibited a unique cytoadherence profile for the three human cell types. These isolates generally adhered well to U937 cells and fresh monocytes, moderately to melanoma cells and poorly to TE 671, MIA-Pa-Ca, WI 38, PLC/PRF/5 and HeLa cells. An antimalarial immunoglobulin pool inhibited binding to melanoma cells by 50% or more and to U937 cells by 25% or less. There was no correlation between in vitro cytoadherence to the three cells and clinical disease. These results suggest that malarial adherence ligands exposed on the surface of infected erythrocytes vary from one isolate to another.
我们观察到，来自马拉维的恶性疟原虫分离株对黑色素瘤细胞、U937细胞和人外周血单核细胞的细胞黏附存在相当大的差异。每个分离株对这三种人类细胞类型都表现出独特的细胞黏附谱。这些分离株通常能很好地黏附于U937细胞和新鲜单核细胞，对黑色素瘤细胞的黏附程度中等，而对TE 671、MIA-Pa-Ca、WI 38、PLC/PRF/5和HeLa细胞的黏附较差。一种抗疟免疫球蛋白库可抑制与黑色素瘤细胞的结合达50%或更多，而对U937细胞的结合抑制率则在25%或更低。体外对这三种细胞的细胞黏附与临床疾病之间没有相关性。这些结果表明，感染红细胞表面暴露的疟疾黏附配体在不同分离株之间存在差异。
