多瘤病毒致癌作用的免疫决定因素。
Immunological determinants of polyoma virus oncogenesis.
作者信息
HABEL K
出版信息
J Exp Med. 1962 Jan 1;115(1):181-93. doi: 10.1084/jem.115.1.181.
Abstract
Adult mice and hamsters can be made resistant to an isologous transplantable polyoma tumor by an inapparent infection with polyoma virus. This resistance is cell-mediated and seems not to be related to anti-viral serum antibodies. The basis of the resistance appears to be a transplantation type of cellular immunity directed against a "foreign" antigen contained in the tumor cell. Evidence has been presented to demonstrate this tumor antigen. It is possible that this phenomenon may explain the lack of oncogenesis by polyoma virus infection of adult mice, and the rarity of naturally occurring polyoma tumors.
摘要
成年小鼠和仓鼠可通过隐性感染多瘤病毒而对同种可移植性多瘤肿瘤产生抗性。这种抗性是细胞介导的，似乎与抗病毒血清抗体无关。抗性的基础似乎是针对肿瘤细胞中所含“外来”抗原的一种移植型细胞免疫。已有证据证明这种肿瘤抗原的存在。这种现象有可能解释成年小鼠感染多瘤病毒后不发生肿瘤形成以及自然发生的多瘤肿瘤罕见的原因。
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