通过荧光原位杂交将人类细胞色素P-450硝苯地平氧化酶基因（CYP3A4）定位于7号染色体q22.1带。
Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization.
作者信息
Inoue K, Inazawa J, Nakagawa H, Shimada T, Yamazaki H, Guengerich F P, Abe T
机构信息
Osaka Prefectural Institute of Public Health, Japan.
出版信息
Jpn J Hum Genet. 1992 Jun;37(2):133-8. doi: 10.1007/BF01899734.
We have used a full length cDNA clone (2.2 kb) for the human cytochrome P-450 nifedipine oxidase (CYP3A4) enzyme as a probe to determine its chromosome localization by fluorescence in situ hybridization. CYP3A4 was mapped on R-banded human prometaphase chromosomes, and the precise localization of CYP3A4 on chromosome 7 was further confirmed by a delineation of G-banded pattern on the same prometaphase chromosomes through a combination of UV-filter. We assigned CYP3A4 to chromosome 7 at q22.1.
我们使用人细胞色素P-450硝苯地平氧化酶（CYP3A4）的全长cDNA克隆（2.2 kb）作为探针，通过荧光原位杂交确定其染色体定位。CYP3A4被定位在经R显带处理的人早中期染色体上，通过紫外线滤光片组合对同一早中期染色体上的G带模式进行描绘，进一步证实了CYP3A4在7号染色体上的精确位置。我们将CYP3A4定位于7号染色体q22.1处。
Zotero 插件