人类细胞色素P450 CYP3基因座：定位于染色体7q22 - qter。
The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.
作者信息
Spurr N K, Gough A C, Stevenson K, Wolf C R
机构信息
Human Genetic Resources, Imperial Cancer Research Fund, Clare Hall Laboratories, Herts, UK.
出版信息
Hum Genet. 1989 Jan;81(2):171-4. doi: 10.1007/BF00293896.
PMID:2563251
Abstract
The cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and chemicals. Using a full length cDNA clone for the human nifedipine oxidase gene (CYP3) and a panel of human-rodent somatic cell hybrids, we have assigned this gene family to chromosome 7q22-qter. A search for RFLPs using this probe yielded no results.
摘要
细胞色素P - 450是一个参与药物和化学物质代谢及解毒的大型多基因酶家族。利用人硝苯地平氧化酶基因（CYP3）的全长cDNA克隆和一组人 - 啮齿动物体细胞杂种，我们已将该基因家族定位于染色体7q22 - qter。用该探针寻找限制性片段长度多态性（RFLP）未得到结果。
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