Martin M V, van Saene H K
University of Liverpool.
Curr Opin Dent. 1992 Sep;2:81-4.
It has been assumed that the principal changes that occur in the oral flora during cancer therapy are yeast and gram-positive coccal proliferation. Recent studies have shown that treatment with topical antifungals or disinfectants has failed to relieve such complications as irradiation mucositis that occur during anticancer therapy. Thus, many of the oral lesions observed during treatment are not due to candidiasis or streptococcal infection. It has been shown that anticancer therapy impairs or reduces the carriage defense of the oropharynx and is accompanied by colonization and proliferation of gram-negative bacilli. It is argued that if oral infectious complications are to be prevented during anticancer therapy, then the selective elimination of gram-negative bacilli may be indicated.
人们一直认为，癌症治疗期间口腔菌群发生的主要变化是酵母菌和革兰氏阳性球菌的增殖。最近的研究表明，局部使用抗真菌药或消毒剂治疗未能缓解抗癌治疗期间出现的诸如放射性口腔炎等并发症。因此，治疗期间观察到的许多口腔病变并非由念珠菌病或链球菌感染引起。研究表明，抗癌治疗会损害或降低口咽的携带防御能力，并伴有革兰氏阴性杆菌的定植和增殖。有人认为，如果要在抗癌治疗期间预防口腔感染并发症，那么可能需要选择性地清除革兰氏阴性杆菌。
