Pezzone M A, Rush K A, Kusnecov A W, Wood P G, Rabin B S
Brain, Behavior and Immunity Center, University of Pittsburgh School of Medicine, Pennsylvania 15213.
Brain Behav Immun. 1992 Sep;6(3):293-9. doi: 10.1016/0889-1591(92)90050-x.
Amphetamine, a neural stimulatory agent with acute effects mimicking those of stress, is shown here to elevate plasma corticosterone levels and suppress spleen and peripheral blood lymphocyte (PBL) mitogenic responses to concanavalin A (Con A) and phytohemagglutinin (PHA) when administered to rats. Pretreatment of the rats with propranolol, a nonselective beta-adrenergic receptor antagonist, totally prevented the amphetamine-induced suppression of lymphocyte mitogenic reactivity to Con A and PHA in the spleen and to PHA in the peripheral blood; however, the PBL mitogenic response to Con A was only partially restored. Although the amphetamine-induced alterations in immune function were prevented by propranolol pretreatment, the elevated plasma corticosterone response was not. This suggests that corticosterone is not modulating the mitogenic activity of splenic lymphocytes or PHA-reactive PBLs. On the other hand, Con A-reactive PBLs may be affected by corticosterone and/or other mechanisms, which may include the catecholamines.
苯丙胺是一种神经刺激剂，其急性效应与应激反应相似。本研究表明，给大鼠注射苯丙胺后，可使血浆皮质酮水平升高，并抑制脾脏和外周血淋巴细胞（PBL）对刀豆球蛋白A（Con A）和植物血凝素（PHA）的促有丝分裂反应。用非选择性β-肾上腺素能受体拮抗剂普萘洛尔对大鼠进行预处理，可完全阻止苯丙胺诱导的脾脏淋巴细胞和外周血淋巴细胞对Con A和PHA以及外周血淋巴细胞对PHA的促有丝分裂反应的抑制；然而，PBL对Con A的促有丝分裂反应仅部分恢复。虽然普萘洛尔预处理可阻止苯丙胺诱导的免疫功能改变，但血浆皮质酮升高的反应并未被阻止。这表明皮质酮并未调节脾脏淋巴细胞或PHA反应性PBL的促有丝分裂活性。另一方面，Con A反应性PBL可能受皮质酮和/或其他机制的影响，其中可能包括儿茶酚胺。
