Stubbs E G, Crawford M L
J Autism Child Schizophr. 1977 Mar;7(1):49-55. doi: 10.1007/BF01531114.
Although there are associations linking autism with prenatal rubella, cytomegalovirus, syphilis, and varicella, the etiology of the autistic state remains obscure. Host defense against the etiologic agents postulated to be responsible for the autism-associated syndromes is believed to be primarily of the cell-mediated type. In this preliminary study, cellular immune function was assessed in vitro by phytohemagglutinin (PHA) stimulation of lymphocyte cultures. Twelve autistic children and 13 control subjects were compared. The autistic group exhibited a depressed lymphocyte transformation response to PHA when compared to the control subjects (p less than .01).
尽管有研究表明自闭症与产前风疹、巨细胞病毒、梅毒和水痘有关，但自闭症状态的病因仍不明确。据推测，针对被认为是自闭症相关综合征病因的病原体的宿主防御主要是细胞介导型的。在这项初步研究中，通过植物血凝素（PHA）刺激淋巴细胞培养物在体外评估细胞免疫功能。对12名自闭症儿童和13名对照受试者进行了比较。与对照受试者相比，自闭症组对PHA的淋巴细胞转化反应较低（p小于0.01）。
