精神分裂症患者血清中针对胸腺细胞的抗体。
Antibodies to thymocytes in sera of patients with schizophrenia.
作者信息
Luria E A, Domashneva I V
出版信息
Proc Natl Acad Sci U S A. 1974 Jan;71(1):235-6. doi: 10.1073/pnas.71.1.235.
Sera from healthy people and from patients with schizophrenia were heated at 56 degrees for 30 min and then kept at 4 degrees . These sera were then tested for cytotoxicity and by the indirect immunofluorescence method with thymocytes, bone-marrow cells, and lymph-node cells of adult C(3)H mice. The cytotoxicity index for mouse thymocytes of sera from 60 healthy donors ranged from 0.00 to 0.4, with an average of 0.08. That of sera from 35 patients with schizophrenia ranged from 0.29 to 0.91, with an average of 0.71. The cytotoxicity index for mouse bone-marrow cells of sera from healthy donors ranged from 0.03 to 0.23, whereas that of sera from patients with schizophrenia ranged from 0.00 to 0.14. Sera of patients at dilutions of 1:8-1:32 displayed immunofluorescence of almost 100% of thymocytes and 58-78% of lymphocytes, whereas sera of healthy donors displayed none. We thus conclude that the sera of patients with schizophrenia contain antibodies against thymic antigens localized on thymocytes and thymus-derived lymphocytes.
将健康人和精神分裂症患者的血清在56摄氏度下加热30分钟，然后保存在4摄氏度。然后用成年C(3)H小鼠的胸腺细胞、骨髓细胞和淋巴结细胞对这些血清进行细胞毒性测试和间接免疫荧光法检测。60名健康供者血清对小鼠胸腺细胞的细胞毒性指数范围为0.00至0.4，平均为0.08。35名精神分裂症患者血清的细胞毒性指数范围为0.29至0.91，平均为0.71。健康供者血清对小鼠骨髓细胞的细胞毒性指数范围为0.03至0.23，而精神分裂症患者血清的细胞毒性指数范围为0.00至0.14。患者血清在1:8 - 1:32稀释度时，几乎100%的胸腺细胞和58 - 78%的淋巴细胞显示免疫荧光，而健康供者血清则无此现象。因此，我们得出结论，精神分裂症患者的血清含有针对位于胸腺细胞和胸腺来源淋巴细胞上的胸腺抗原的抗体。
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