Luo K
Nanfang Hospital, First Military Medical College, Guangzhou.
Zhonghua Liu Xing Bing Xue Za Zhi. 1992 Apr;13(2):65-7.
The hepatitis B virus (HBV) infection usually occurs during infancy and children. To elucidate how the infection changes during the elderly life, 2233 residents were surveyed and among them 440 individuals with the age of 60-96 years were centered for analysis. The infection in the elderly was decreasing. HBsAg prevalence (5.0%) and titer (3.5 +/- 2.3) were getting lower, nearly all HBeAg seroconverted to anti-HBe, and the infection might be cleared at last. However, the HBV antibody prevalence steadily maintained, implying frequent HBV exposure and antibody responses during aging in the endemic area. Among them no fresh HBsAg were detected at one year follow-up, but antibodies developed in 10.8% of 65 individuals without HBV markers initially, and more, in 79 with single anti-HBs or anti-HBc 6.3% developed another antibody in a year. Therefore, the elderly population might be in a hypo-infection and dynamic hyperimmune status of the hepatitis B virus.
乙肝病毒（HBV）感染通常发生在婴幼儿期。为了阐明老年期感染情况如何变化，对2233名居民进行了调查，其中以440名年龄在60 - 96岁的个体为分析对象。老年人中的感染率在下降。HBsAg流行率（5.0%）和滴度（3.5±2.3）降低，几乎所有HBeAg都血清转化为抗-HBe，感染最终可能被清除。然而，HBV抗体流行率稳定维持，这意味着在乙肝流行地区，老年人在衰老过程中频繁接触HBV并产生抗体反应。在他们当中，一年随访时未检测到新的HBsAg，但最初无HBV标志物的65名个体中有10.8%产生了抗体，此外，在79名单一抗-HBs或抗-HBc阳性者中，有6.3%在一年内又产生了另一种抗体。因此，老年人群可能处于乙肝病毒低感染和动态高免疫状态。
