[湖南地区乙型肝炎病毒感染的血清流行病学研究]

[Seroepidemiological study of HBV infection in Hunan area].

作者信息

Xiao Y J

机构信息

Department of Epidemiology, Hunan Medical University.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1990 Jun;11(3):133-7.

PMID:2390776

Abstract

A seroepidemiological study of HBV infection was carried out in a "normal population" of 3,089 in Hunan area by means of SPRIA and ELISA in 1983-1986. The positivity rates of HBsAg, anti-HBs and anti-HBc were 17.87%, 31.76% and 73.03% respectively. The overall rate of HBV infection was 80.77%, All the positive rates of HBsAg, anti-HBs and anti-HBc peak at the age of 10-15 years, then, it remains on a similar level. This results indicate that Hunan is a high epidemic area of HBV and the age of persons at peak infection rate is very young. About half of HBsAg positive persons is HBeAg positive and a part of persons who are both HBsAg and HBeAg positive has the lesion of liver function. Thus these persons could be the reservoirs of HBV infection and it was necessary to treat and deal with them seriously.

摘要

1983 - 1986年期间，采用固相放射免疫分析（SPRIA）和酶联免疫吸附测定（ELISA）方法，对湖南地区3089名“正常人群”进行了乙肝病毒（HBV）感染的血清流行病学研究。乙肝表面抗原（HBsAg）、乙肝表面抗体（抗-HBs）和乙肝核心抗体（抗-HBc）的阳性率分别为17.87%、31.76%和73.03%。HBV感染的总体率为80.77%。所有HBsAg、抗-HBs和抗-HBc的阳性率在10 - 15岁时达到峰值，然后维持在相似水平。这些结果表明，湖南是HBV的高流行区，感染率峰值人群的年龄非常小。约一半的HBsAg阳性者HBeAg阳性，部分HBsAg和HBeAg均阳性者有肝功能损害。因此，这些人可能是HBV感染的储存宿主，有必要对其进行认真的治疗和处理。