痘苗病毒编码的白细胞介素-1β可溶性受体：病毒调节宿主感染反应的一种新机制。

A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infection.

作者信息

Alcamí A, Smith G L

机构信息

Sir William Dunn School of Pathology, University of Oxford, England.

出版信息

Cell. 1992 Oct 2;71(1):153-67. doi: 10.1016/0092-8674(92)90274-g.

DOI:10.1016/0092-8674(92)90274-g

PMID:1394428

Abstract

Vaccinia virus gene B15R is shown to encode an abundant, secretory glycoprotein that functions as a soluble interleukin-1 (IL-1) receptor. This IL-1 receptor has novel specificity since, in contrast with cellular counterparts, it binds only IL-1 beta and not IL-1 alpha or the natural competitor IL-1 receptor antagonist. The vaccinia IL-1 beta receptor is secreted when expressed in a baculovirus system and competitively inhibited binding of IL-1 beta to the natural receptor on T cells. Deletion of B15R from vaccinia virus accelerated the appearance of symptoms of illness and mortality in intranasally infected mice, suggesting that the blockade of IL-1 beta by vaccinia virus can diminish the systemic acute phase response to infection and modulate the severity of the disease. The IL-1 beta binding activity is present in other orthopoxviruses.

摘要

痘苗病毒基因B15R被证明编码一种丰富的分泌性糖蛋白，其作为可溶性白细胞介素-1（IL-1）受体发挥作用。这种IL-1受体具有新的特异性，因为与细胞对应物不同，它只结合IL-1β，而不结合IL-1α或天然竞争物IL-1受体拮抗剂。痘苗IL-1β受体在杆状病毒系统中表达时会分泌出来，并竞争性抑制IL-1β与T细胞上天然受体的结合。从痘苗病毒中缺失B15R会加速鼻内感染小鼠疾病症状和死亡的出现，这表明痘苗病毒对IL-1β的阻断可以减少对感染的全身急性期反应并调节疾病的严重程度。IL-1β结合活性存在于其他正痘病毒中。