De Vita S, Lorenzon G, Rossi G, Sabella M, Fossaluzza V
Clinical Immunology Unit, University of Pisa, Italy.
Clin Exp Rheumatol. 1992 Jul-Aug;10(4):351-6.
A series of different ultrasonographic abnormalities detected by salivary gland echography (SGE) were investigated for their discriminant power for Sjögren's syndrome (SS) in 53 patients with either primary SS (n = 27) or secondary SS (n = 26), as well as in 90 controls. Among the controls, 26 suffered from dry mouth and/or recurrent or persistent swelling of at least one parotid or submandibular gland due to other selected disorders, while 64 were healthy, asymptomatic subjects. Mild, evident or gross inhomogeneous parenchymal patterns were the only variables selected by stepwise discriminant analysis, when comparing patients to controls. However, a mild submandibular inhomogeneity did not prove useful for such a discrimination. Based on these data, a simplified evaluation and standardised quantification of salivary involvement, as detected by SGE, is proposed using an echographic score (range 0 to 6) which assigns points to the different degrees of glandular inhomogeneity. Score values above 0 showed a sensitivity of 88.8% in primary SS and of 53.8% in secondary SS, as well as a specificity of 84.6% and of 92.2% with respect to either symptomatic or healthy controls. The lower sensitivity of SGE for patients with secondary SS presumably was a result of their milder salivary involvement.
通过唾液腺超声检查（SGE）检测到的一系列不同超声异常，在53例原发性干燥综合征（pSS，n = 27）或继发性干燥综合征（sSS，n = 26）患者以及90例对照中，研究了它们对干燥综合征（SS）的判别能力。在对照中，26例因其他特定疾病患有口干和/或至少一侧腮腺或颌下腺反复或持续肿胀，而64例为健康无症状受试者。在将患者与对照进行比较时，轻度、明显或严重的实质不均匀模式是逐步判别分析中唯一选择的变量。然而，轻度颌下不均匀性对这种判别并无帮助。基于这些数据，提出了一种简化的评估方法，并对SGE检测到的唾液受累情况进行标准化量化，使用超声评分（范围0至6），该评分根据不同程度的腺体不均匀性进行评分。评分值高于0时，对原发性干燥综合征的敏感性为88.8%，对继发性干燥综合征为53.8%，对有症状或健康对照的特异性分别为84.6%和92.2%。SGE对继发性干燥综合征患者的敏感性较低，可能是由于其唾液受累较轻。
