Kiviranta I, Tammi M, Jurvelin J, Arokoski J, Säämänen A M, Helminen H J
Department of Surgery, University Hospital of Kuopio, Finland.
Clin Orthop Relat Res. 1992 Oct(283):302-8.
The influences of the strenuous running training program on the knee joint articular cartilage was studied in six female beagle dogs. At the age of 15 weeks, the dogs started running on a treadmill inclined 15 degrees uphill. Thereafter, the dogs were trained for 40 weeks, five times a week. For the final 15 weeks, the dogs ran 20 km/day. Six age-matched female beagles served as controls. The cartilage surfaces were intact after the running exercise. The training reduced the thickness of the uncalcified cartilage by 6% in the medial femoral condyle. The glycosaminoglycan concentration was reduced an average of 11% on the summits of the femoral condyles. The reduction was most pronounced (41%) in the superficial 50-micron cartilage zone. In other regions of the knee, such a decrease of glycosaminoglycans was not observed. A shift to strenuous running voided the increase in cartilage thickness and proteoglycan content previously observed after moderate running. Strenuous running induced marked depletion of proteoglycans from the superficial layer of the femoral condyles at sites subjected to highest impact loads.
在6只雌性比格犬身上研究了高强度跑步训练计划对膝关节软骨的影响。在15周龄时，这些狗开始在倾斜15度的上坡跑步机上跑步。此后，这些狗每周训练5次，持续40周。在最后15周，这些狗每天跑20公里。6只年龄匹配的雌性比格犬作为对照。跑步锻炼后软骨表面完好无损。训练使股骨内侧髁未钙化软骨的厚度减少了6%。股骨髁顶端的糖胺聚糖浓度平均降低了11%。在浅表50微米软骨区域减少最为明显（41%）。在膝关节的其他区域，未观察到糖胺聚糖的这种减少。转向高强度跑步消除了先前在适度跑步后观察到的软骨厚度和蛋白聚糖含量的增加。高强度跑步导致股骨髁表层在承受最高冲击负荷的部位蛋白聚糖显著耗竭。
