Terao S, Sobue G, Mitsuma T
Fourth Department of Internal Medicine, Aichi Medical University.
Rinsho Shinkeigaku. 1992 Apr;32(4):370-4.
The myelinated fibers in the lateral corticospinal tract at the C6, T7, L4 levels in amyotrophic lateral sclerosis (ALS) and control cases were morphometrically examined. ALS cases consisted of 6 males and 2 females with ages ranging between 48 and 85 years, and were all the common or bulbar form in clinical manifestation. As for controls, 10 cases who died of non-neurological diseases, with age ranging 36 to 90 years were served. The population and the diameter profile of the myelinated fibers in the corticospinal tract of the C6, T7, L4 levels were measured by the method previously described and expressed as number per mm2. In control subjects, fiber-size histograms of myelinated fibers showed a bimodal pattern with a sharp peak of small fibers (less than 7.28 microns) and a broad peak of large fibers (greater than or equal to 7.28 microns) in all the spinal levels. In ALS cases, large myelinated fibers were predominantly diminished in number, a small myelinated fibers were also decreased in some cases. The degree of fiber loss was extremely variable among cases; well populated in large fibers in some cases. As for the rostral caudal distribution of myelinated fiber loss, a caudally-accentuated fiber loss particularly in large fiber was seen in some of the cases. The topographical distribution of fiber loss in the horizontal plane of the corticospinal tract in ALS did not show a distinctive pattern.
对肌萎缩侧索硬化症（ALS）患者和对照病例C6、T7、L4水平的外侧皮质脊髓束中的有髓纤维进行了形态计量学检查。ALS病例包括6名男性和2名女性，年龄在48至85岁之间，临床表现均为常见型或延髓型。对照组为10例死于非神经系统疾病的患者，年龄在36至90岁之间。采用前述方法测量C6、T7、L4水平皮质脊髓束中有髓纤维的数量和直径，并以每平方毫米的数量表示。在对照受试者中，有髓纤维的纤维大小直方图呈双峰模式，在所有脊髓水平上，小纤维（小于7.28微米）有一个尖锐峰值，大纤维（大于或等于7.28微米）有一个宽峰。在ALS病例中，大的有髓纤维数量主要减少，一些病例中小的有髓纤维也减少。病例之间纤维损失的程度差异极大；在某些病例中，大纤维数量较多。至于有髓纤维损失的头尾分布，在一些病例中，特别是大纤维，可见尾部明显的纤维损失。ALS患者皮质脊髓束水平面纤维损失的地形分布没有显示出明显的模式。
