Oyanagi K, Makifuchi T, Ikuta F
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan.
Acta Neuropathol. 1995;90(3):221-7. doi: 10.1007/BF00296504.
We carried out a morphometric study on the myelinated fibers in the anterolateral funiculus (ALF) and lateral corticospinal tract (LCS) in the cervical segment of the spinal cord of 13 patients with classic amyotrophic lateral sclerosis (ALS), 6 of whom had been on a respirator; 5 age-matched subjects were used as controls. The results obtained revealed that: (1) the fiber-size distributions of the myelinated fibers in the ALF and LCS of the control subjects had peaks at 2 microns; (2) there were marked and significant losses of large myelinated fibers in the ALF and LCS of ALS patients; (3) the patients who required respirator support showed more severe degeneration in the ALF than those who required none; and (4) the degree of myelinated fiber loss in the LCS did not correlate with either the illness duration or the history of respirator use.
我们对13例经典肌萎缩侧索硬化症（ALS）患者脊髓颈段的前外侧索（ALF）和皮质脊髓侧束（LCS）中的有髓纤维进行了形态计量学研究，其中6例患者使用了呼吸机；选取5名年龄匹配的受试者作为对照。所得结果显示：（1）对照受试者的ALF和LCS中有髓纤维的纤维大小分布在2微米处有峰值；（2）ALS患者的ALF和LCS中存在明显且显著的大直径有髓纤维损失；（3）需要呼吸机支持的患者其ALF中的变性比不需要呼吸机支持的患者更严重；（4）LCS中有髓纤维的损失程度与病程或呼吸机使用史均无相关性。
