Sobue G, Hashizume Y, Mitsuma T, Takahashi A
Neurology. 1987 Mar;37(3):529-32. doi: 10.1212/wnl.37.3.529.
Morphometric evaluation was performed on myelinated fibers of the corticospinal tract at the seventh thoracic spinal cord segment from three patients with Shy-Drager syndrome (SDS), six patients with amyotrophic lateral sclerosis (ALS), and five patients with nonneurologic symptoms. In SDS, small-sized myelinated fibers were nearly completely depleted, while large-sized myelinated fibers were considerably well preserved. In ALS, on the contrary, large myelinated fibers were predominantly decreased. These results suggested that selective vulnerability of axonal loss depends on fiber size and should be considered in interpretation of pathology of corticospinal tracts.
对3例Shy-Drager综合征（SDS）患者、6例肌萎缩侧索硬化症（ALS）患者和5例无神经症状患者的第7胸髓节段皮质脊髓束的有髓纤维进行了形态计量学评估。在SDS中，小直径有髓纤维几乎完全缺失，而大直径有髓纤维保存相当完好。相反，在ALS中，主要是大直径有髓纤维减少。这些结果表明，轴突丢失的选择性易损性取决于纤维大小，在解释皮质脊髓束的病理学特征时应予以考虑。
