Parra S, Garcia J, Martinez P, de la Peña C, Carrascosa C
Clinical Analyses Service, Virgen de la Arrixaca University Hospital, Murcia, Spain.
Dig Dis Sci. 1992 Oct;37(10):1495-8. doi: 10.1007/BF01296492.
Mushrooms of the genus Lepiota (helveola and bruneo-incarnata), similar to those of the genus Amanita, contain amatoxins. Amatoxins, especially amanitin, cause cellular destruction by inhibiting RNA polymerase. Due to the hepatic toxicity of these mushrooms, we have assessed their incidence on alkaline phosphatase levels and on its isoenzymes. Total alkaline phosphatase activity levels were not found to be increased except in two patients, and then only moderately. As regards isoenzymes, the occurrence of a double hepatic fraction in five of the 10 patients, is the most remarkable finding. There seems to exist a relatively close correspondence between the occurrence of a hepatic2 fraction correlating with those of urine amanitin. We conclude that the hepatic2 fraction proves to be important in assessing liver damage by mushroom poisoning because of its correlation with the patient's degree of poisoning.
环柄菇属（赭盖环柄菇和褐肉环柄菇）的蘑菇与鹅膏菌属的蘑菇类似，含有鹅膏毒素。鹅膏毒素，尤其是鹅膏毒肽，通过抑制RNA聚合酶导致细胞破坏。由于这些蘑菇具有肝脏毒性，我们评估了它们对碱性磷酸酶水平及其同工酶的影响。除了两名患者外，未发现总碱性磷酸酶活性水平升高，而且只是轻度升高。关于同工酶，10名患者中有5名出现双肝部分，这是最显著的发现。与尿鹅膏毒肽相关的肝2部分的出现之间似乎存在相对密切的对应关系。我们得出结论，肝2部分因其与患者中毒程度的相关性，在评估蘑菇中毒引起的肝损伤方面被证明是重要的。
