Joshi A, Chandrasoma P, Kiyabu M
Department of Pathology, Los Angeles County-University of Southern California Medical Center 90033.
Dig Dis Sci. 1992 Oct;37(10):1612-8. doi: 10.1007/BF01296510.
A 52-year-old woman initially presented to our medical center with synchronous, submucosal tumors of the esophagus, stomach, and transverse colon. The gastric and colonic tumors were resected, and both displayed infiltrating sheets of polygonal cells with coarsely granular cytoplasm and small vesicular nuclei. The neoplastic cells of both tumors were immunoreactive for S-100 protein. Ultrastructural studies revealed the lysosomal nature of the cytoplasmic granules. Although the esophageal mass was not resected, it was felt that this represented another focus of granular cell tumor of the gastrointestinal tract. Two years later, she presented with disseminated squamous carcinoma of the esophagus. At autopsy, a submucosal granular cell tumor was found adjacent to the squamous carcinoma of the esophagus. To our knowledge, this is the first reported case of synchronous granular cell tumors that involved multiple segments of the gastrointestinal tract, one of which was later associated with a squamous carcinoma of the esophagus.
一名52岁女性最初因食管、胃和横结肠同时出现黏膜下肿瘤而就诊于我们的医疗中心。胃和结肠肿瘤被切除，二者均显示为多边形细胞浸润片，细胞质粗糙呈颗粒状，细胞核小且呈泡状。两种肿瘤的肿瘤细胞对S-100蛋白均呈免疫反应性。超微结构研究揭示了细胞质颗粒的溶酶体性质。尽管食管肿物未被切除，但认为这代表了胃肠道颗粒细胞瘤的另一个病灶。两年后，她出现了食管播散性鳞状细胞癌。尸检时，在食管鳞状细胞癌旁发现了一个黏膜下颗粒细胞瘤。据我们所知，这是首例报道的同时累及胃肠道多个节段的颗粒细胞瘤病例，其中一个节段后来与食管鳞状细胞癌相关。
