Szumiło J, Skomra D, Zinkiewicz K, Zgodziński W
Department of Pathomorphology, Medical University of Lublin.
Ann Univ Mariae Curie Sklodowska Med. 2001;56:253-6.
Granular cell tumours (GCTs) are relatively uncommon, usually benign and solitary neoplasms. Approximately 5-11% of all tumours occur in the gastrointestinal tract and about one third of them appear in the esophagus. Till now, only 30 cases of multiple esophageal GCTs have been reported in the literature. We present the case of a 44-year-old man with three synchronous GCTs in the distal esophagus. The lesions were detected incidentally during esophagoscopy. Histopathologic examination of tissue samples revealed the nests of polygonal cells with small hyperchromatic nuclei and abundant granular cytoplasm located in the lamina propria of the mucosa. The cytoplasmic granules were positively stained with PAS and were diastase resistant. The positive immunostaining for S-100 protein was also noted.
颗粒细胞瘤（GCTs）是相对罕见的，通常为良性且孤立的肿瘤。所有肿瘤中约5-11%发生于胃肠道，其中约三分之一出现在食管。迄今为止，文献中仅报道了30例多发性食管颗粒细胞瘤。我们报告一例44岁男性患者，其远端食管有三个同步发生的颗粒细胞瘤。这些病变在食管镜检查时偶然被发现。组织样本的组织病理学检查显示，在黏膜固有层中有多边形细胞巢，细胞核小且深染，细胞质丰富呈颗粒状。细胞质颗粒经PAS染色呈阳性且耐淀粉酶。同时也观察到S-100蛋白免疫染色呈阳性。
