Menzel T, Lambertz H, Rau G
Fachbereich Kardiologie, Deutsche Klinik für Diagnostik, Wiesbaden.
Dtsch Med Wochenschr. 1992 Oct 2;117(40):1518-24. doi: 10.1055/s-2008-1062473.
A 51-year-old man and a 39-year-old woman with the hypereosinophilic syndrome developed a restrictive cardiomyopathy in the course of cardiac involvement. Echocardiography demonstrated typical thrombotic obliteration at the apex of both ventricles. Doppler ultrasound showed changes of impaired filling in both ventricles. Glucocorticoid treatment (prednisone, 85 mg daily) had to be drastically reduced (to 10 mg daily) in case 1, because of the development of a Cushing syndrome. The man died 18 months later of advanced heart failure. In the woman the eosinophil count fell after prednisone administration (1 mg/kg daily) and there was no recurrence. But heart failure due to impaired diastolic filling has persisted so that orthotopic cardiac transplantation has been planned.
一名51岁男性和一名39岁女性患有嗜酸性粒细胞增多综合征，在心脏受累过程中发展为限制性心肌病。超声心动图显示两个心室心尖部有典型的血栓性闭塞。多普勒超声显示两个心室充盈受损的改变。在病例1中，由于库欣综合征的出现，糖皮质激素治疗（泼尼松，每日85毫克）不得不大幅减少（至每日10毫克）。该男性18个月后死于晚期心力衰竭。在女性患者中，服用泼尼松（每日1毫克/千克）后嗜酸性粒细胞计数下降，且未复发。但由于舒张期充盈受损导致的心力衰竭持续存在，因此已计划进行原位心脏移植。
