Mrejen S, Quinonero J, Moinard F, Ghandour S, Jacque C
INSERM U-134, Hôpital de la Salpêtrière, Paris, France.
Dev Neurosci. 1992;14(2):144-52. doi: 10.1159/000111658.
Neoangiogenesis of transplants implanted into the brains of newborn rodent hosts was evaluated by immunohistochemistry for 2 weeks after the operation. The use of species-specific antibodies directed against mouse endothelial cells demonstrated the respective participation of the host and the donor in the formation of new vessels in the graft after crossed rabbit into mouse and mouse into rat transplantation experiments. We show that blood vessels made by host endothelial cells begin to penetrate the transplant 24 h after grafting, and cross it completely by 72 h. Simultaneously, host astrocytes invade the transplant.
通过免疫组织化学方法对移植到新生啮齿动物宿主脑内的移植物的新生血管生成情况进行了术后2周的评估。在兔到小鼠以及小鼠到大鼠的移植实验中，使用针对小鼠内皮细胞的种属特异性抗体证明了宿主和供体各自在移植物新血管形成中的参与情况。我们发现，宿主内皮细胞形成的血管在移植后24小时开始穿透移植物，并在72小时时完全穿过。同时，宿主星形胶质细胞侵入移植物。
