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全内镜检查的理由与争议——综述

The justifications and controversies of panendoscopy--a review.

作者信息

Levine B, Nielsen E W

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia.

出版信息

Ear Nose Throat J. 1992 Aug;71(8):335-40, 343.

PMID:1396181
Abstract

The triple endoscopies of direct laryngoscopy, bronchoscopy, and esophagoscopy, commonly known as panendoscopy, are frequent surgical procedures in otorhinolaryngology. Their purpose is to diagnose additional primary malignancies. The incidence of multiple synchronous primary malignancies has been reported between 3% and 13%. This unusually high rate is attributed to the process of field cancerization in which an anatomical region is exposed to a surface carcinogen and multifocal areas undergo irreversible change to multifocal malignancies. The majority of additional malignancies are diagnosed within 2 years of the index tumor's diagnosis, and are most consistently diagnosed within routine panendoscopy. Nevertheless, a significant percentage (40%) of additional primary malignancies present after this time and consequently, long-term follow-up is essential to the timely diagnosis of metachronous lesions. The predominant controversies surrounding panendoscopy involve the comparable diagnostic efficacies between endoscopic procedures and various radiologic studies. Although the operative complications reported for panendoscopy have been minimal, the expense is considerably greater than that of the respective radiologic alternatives. After a critical review of the literature, the use of endoscopy has been found to be superior to CXRs and barium swallows as the principal means of diagnosis of upper aerodigestive tract cancers. Specifically, bronchoscopy with bronchial washings should be obtained via passage of the bronchoscope through the endotracheal tube in order to decrease contamination. Positive washings are significant and demand further evaluation. Negative washings, on the other hand, yield little information.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

直接喉镜检查、支气管镜检查和食管镜检查这三种内镜检查,通常称为全内镜检查,是耳鼻喉科常见的外科手术。其目的是诊断额外的原发性恶性肿瘤。据报道,多原发性同步恶性肿瘤的发生率在3%至13%之间。这种异常高的发生率归因于场癌变过程,即解剖区域暴露于表面致癌物,多灶性区域发生不可逆变化成为多灶性恶性肿瘤。大多数额外的恶性肿瘤在索引肿瘤诊断后的2年内被诊断出来,并且最常在常规全内镜检查中被诊断出来。然而,相当比例(40%)的额外原发性恶性肿瘤在此之后出现,因此,长期随访对于及时诊断异时性病变至关重要。围绕全内镜检查的主要争议涉及内镜检查程序与各种放射学研究之间的可比诊断效能。尽管报道的全内镜检查手术并发症极少,但其费用比相应的放射学检查要高得多。在对文献进行严格审查后,发现内镜检查作为上消化道呼吸道癌症的主要诊断手段优于胸部X线检查和钡餐检查。具体而言,应通过将支气管镜经气管插管插入来进行支气管镜检查及支气管灌洗,以减少污染。灌洗结果阳性意义重大,需要进一步评估。另一方面,灌洗结果阴性提供的信息很少。(摘要截选于250字)

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Eur Arch Otorhinolaryngol. 2015 Jul;272(7):1769-75. doi: 10.1007/s00405-014-3125-0. Epub 2014 Jun 7.
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HPV status and second primary tumours in oropharyngeal squamous cell carcinoma.HPV 状态与口咽鳞状细胞癌中的第二原发肿瘤。
J Otolaryngol Head Neck Surg. 2013 May 29;42(1):36. doi: 10.1186/1916-0216-42-36.
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Positive findings on barium swallow in patients presenting with a "sensation of a lump in the throat".钡餐吞咽检查结果阳性的患者表现为“喉咙有异物感”。
Eur Arch Otorhinolaryngol. 2012 Mar;269(3):1047-50. doi: 10.1007/s00405-011-1741-5. Epub 2011 Aug 18.
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The role of barium swallow in the management of the globus pharyngeus.吞咽钡剂造影在咽异感症管理中的作用。
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Eur Arch Otorhinolaryngol. 2005 Jan;262(1):17-20. doi: 10.1007/s00405-004-0743-y. Epub 2004 Mar 5.