Hedenbro J L, Ekelund M, Jansson O, Lindblom A
Department of Surgery, Lund University, Sweden.
Endoscopy. 1992 Aug;24(6):585-7. doi: 10.1055/s-2007-1010550.
Reduction of discomfort during diagnostic upper endoscopy may not be desired by patients if the medication has long-lasting and severe after-effects. The present study was designed to examine whether topical anaesthesia of the pharynx without concomitant sedation is of overall benefit to patients undergoing diagnostic upper endoscopy. Two hundred out-patients were randomized to receive in the form of a pharyngeal spray either 80-120 mg lidocaine or placebo. Patients assessed discomfort on a 100 mm visual analogue scale the day after examination. Patients undergoing endoscopy who received lidocaine spray experienced significantly less discomfort from the intubation (p = 0.0001), and discomfort induced by the rest of the examination was also reduced (p = 0.003). The outcome of the endoscopists' assessment was also in favour of lidocaine spray for intubation (p = 0.157) and ease of examination (p = 0.0014). The assessment of throat discomfort suffered by patients after endoscopy did not differ between the groups. A majority of patients, the same proportion in each group, stated they would prefer their next endoscopy to be performed with topical anaesthesia.
如果药物有长期且严重的后遗症，患者可能并不希望在诊断性上消化道内镜检查期间减轻不适。本研究旨在探讨咽部局部麻醉且不伴有镇静对接受诊断性上消化道内镜检查的患者是否具有总体益处。200名门诊患者被随机分组，以咽喷雾剂的形式接受80 - 120毫克利多卡因或安慰剂。患者在检查后一天用100毫米视觉模拟量表评估不适程度。接受利多卡因喷雾的内镜检查患者插管时的不适明显减轻（p = 0.0001），检查其余部分引起的不适也有所减轻（p = 0.003）。内镜检查医生对插管（p = 0.157）和检查便利性（p = 0.0014）的评估结果也支持利多卡因喷雾。两组患者内镜检查后喉咙不适的评估没有差异。大多数患者，每组比例相同，表示他们希望下次内镜检查采用局部麻醉。
