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患有和未患有慢性阻塞性肺病(COPD)的马的支气管肺泡灌洗液中的花生四烯酸代谢物。

Arachidonate metabolites in bronchoalveolar lavage fluid from horses with and without COPD.

作者信息

Watson E D, Sweeney C R, Steensma K A

机构信息

Department of Clinical Studies, New Bolton Center, Kennett Square, PA 19348.

出版信息

Equine Vet J. 1992 Sep;24(5):379-81. doi: 10.1111/j.2042-3306.1992.tb02859.x.

Abstract

Arachidonate metabolites were measured in bronchoalveolar lavage fluid (BALF) from horses with (N = 4) and without (N = 7) chronic obstructive pulmonary disease (COPD). Prostaglandin (PG) D2, leukotriene (LT) B4 and LTC4 were present in highest concentrations in BALF from clinically normal horses. Concentrations of PGE2 and PGF were significantly higher in BALF from horses with COPD than in BALF from normal horses, but no differences were detected in thromboxane B2, 6-keto-PGF1 alpha, PGD2, LTB4 or LTC4.

摘要

在患有(N = 4)和未患有(N = 7)慢性阻塞性肺疾病(COPD)的马的支气管肺泡灌洗液(BALF)中测量了花生四烯酸代谢物。在临床正常马的BALF中,前列腺素(PG)D2、白三烯(LT)B4和LTC4的浓度最高。患有COPD的马的BALF中PGE2和PGF的浓度显著高于正常马的BALF,但在血栓素B2、6-酮-PGF1α、PGD2、LTB4或LTC4中未检测到差异。

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