Johnson D M, Jones R N
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
Eur J Clin Microbiol Infect Dis. 1992 Feb;11(2):181-8. doi: 10.1007/BF01967075.
BK-218 is a novel cephalosporin with a dual route of administration and spectrum of activity most similar to that of second-generation cephalosporins. BK-218 was active against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis but strains resistant to penicillins had higher MICs. BK-218 had greater activity (8-fold) than cefuroxime or cefaclor against oxacillin-susceptible Staphylococcus spp. Moderate BK-218 activity was observed against Neisseria gonorrhoeae and commonly isolated Enterobacteriaceae such as Escherichia coli (MIC90, 1 mg/l), Klebsiella spp. (MIC90, 2 mg/l), and Proteus mirabilis (MIC90, 2 mg/l). The following organisms were generally BK-218-resistant (MIC90, greater than 16 mg/l): Bacteroides fragilis, Pseudomonas spp., Acinetobacter spp., Xanthomonas maltophilia, Citrobacter spp., Enterobacter spp., indole-positive Proteus, Serratia spp., enterococci and oxacillin-resistant staphylococci.
BK - 218是一种新型头孢菌素，具有双给药途径，其活性谱与第二代头孢菌素最为相似。BK - 218对肺炎链球菌、流感嗜血杆菌和卡他莫拉菌有活性，但对青霉素耐药的菌株有更高的最低抑菌浓度（MIC）。BK - 218对苯唑西林敏感的葡萄球菌属的活性比头孢呋辛或头孢克洛高8倍。观察到BK - 218对淋病奈瑟菌和常见分离的肠杆菌科细菌如大肠埃希菌（MIC90，1mg/L）、克雷伯菌属（MIC90，2mg/L）和奇异变形杆菌（MIC90，2mg/L）有中等活性。以下微生物通常对BK - 218耐药（MIC90，大于16mg/L）：脆弱拟杆菌、假单胞菌属、不动杆菌属、嗜麦芽窄食单胞菌、柠檬酸杆菌属、肠杆菌属、吲哚阳性变形杆菌、沙雷菌属、肠球菌和耐苯唑西林葡萄球菌。
