新型口服及注射用头孢菌素BK-218的体外研究

In vitro investigation of BK-218, a new oral and parenteral cephalosporin.

作者信息

Szabó I, Barabás J, Tar A, Kiss L, Filep M, Schmidt T, Marossy K, Tóth-Martinez B, Barabás G, Hernádi F

机构信息

Institute of Biology, University Medical School, Debrecen, Hungary.

出版信息

Antimicrob Agents Chemother. 1990 Feb;34(2):349-54. doi: 10.1128/AAC.34.2.349.

DOI:10.1128/AAC.34.2.349

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171585/

Abstract

The antibacterial activity of BK-218 was similar to that of cefamandole when it was tested against several laboratory strains. The inhibiting effect of BK-218 was greater than that of cephalexin and cefoxitin on penicillin-binding proteins of Escherichia coli HB101. This result was in close correlation with the relative inhibition of radiolabeled glucosamine incorporation (greatest with BK-218) and with the lytic effect (most intensive with BK-218). BK-218 proved to be a good inhibitor for all five of the beta-lactamases that were investigated, although two enzymes (Enterobacter cloacae P99 and Pseudomonas aeruginosa Cilote) hydrolyzed it to some extent.

摘要

在针对几种实验室菌株进行测试时，BK - 218的抗菌活性与头孢孟多相似。BK - 218对大肠杆菌HB101青霉素结合蛋白的抑制作用大于头孢氨苄和头孢西丁。这一结果与放射性标记葡糖胺掺入的相对抑制作用（BK - 218的抑制作用最强）以及裂解作用（BK - 218的裂解作用最强烈）密切相关。尽管两种酶（阴沟肠杆菌P99和铜绿假单胞菌Cilote）会对BK - 218进行一定程度的水解，但BK - 218被证明是所研究的所有五种β - 内酰胺酶的良好抑制剂。

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