Carr L A, Basham J K, York B K, Rowell P P
Department of Pharmacology and Toxicology, University of Louisville, KY 40292.
Eur J Pharmacol. 1992 May 14;215(2-3):285-7. doi: 10.1016/0014-2999(92)90040-b.
To determine whether the attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity by tobacco smoke exposure is caused by inhibition of the neuronal uptake of 4-phenylpyridinium ion (MPP+), various tobacco components and a smoke extract were tested for inhibitory activity in striatal synaptosomes. A dimethylsulfoxide extract of tobacco smoke filtrate was found to inhibit the uptake of MPP+ and dopamine. These results suggest that inhibition of the neuronal dopamine uptake mechanism may account for the protective effects of smoke exposure on MPTP-induced neurotoxicity.
为了确定烟草烟雾暴露对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的神经毒性的减弱作用是否是由对4-苯基吡啶离子（MPP+）的神经元摄取的抑制所引起的，对各种烟草成分和一种烟雾提取物进行了纹状体突触体中的抑制活性测试。发现烟草烟雾滤液的二甲基亚砜提取物可抑制MPP+和多巴胺的摄取。这些结果表明，对神经元多巴胺摄取机制的抑制可能是烟雾暴露对MPTP诱导的神经毒性的保护作用的原因。
