Tang B K, Inaba T, Kalow W
Drug Metab Dispos. 1977 Jan-Feb;5(1):71-4.
After oral administration of 14C-labeled pentobarbital to healthy subjects, most ot the radioactivity was recovered in urine over a period of 6 days. Only a minute amount (approximately 1%) of unchanged pentobarbital was found in the urine. Four major metabolites were found and isolated. One was 3'-hydroxypentobarbital, which has been previously identified by Maynert. The second could be identified as N-hydroxypentobarbital on the basis of its spectral and chemical properties. The other two metabolites were not identified.
给健康受试者口服14C标记的戊巴比妥后，在6天的时间里，大部分放射性物质在尿液中被回收。尿液中仅发现极少量（约1%）未变化的戊巴比妥。发现并分离出了四种主要代谢物。一种是3'-羟基戊巴比妥，此前已被梅纳特鉴定出来。第二种根据其光谱和化学性质可鉴定为N-羟基戊巴比妥。另外两种代谢物未被鉴定出来。
