戊巴比妥人体代谢的多剂量研究。
Multidose studies in the human metabolism of pentobarbitone.
作者信息
Baldeo W C, Gilbert J N, Powell J W
出版信息
Eur J Drug Metab Pharmacokinet. 1980;5(2):75-80. doi: 10.1007/BF03189449.
PMID:7398680
Abstract
The metabolism of pentobarbitone has been investigated in two healthy volunteers, and the urinary excretion of unchanged drug, and the products of omega- and (omega-1)-oxidation, quantified for four days after each of three doses to each volunteer. The rates of excretion are discussed in terms which include enzyme induction effects.
摘要
在两名健康志愿者身上研究了戊巴比妥的代谢情况，对每名志愿者给予三次剂量中的每一次后，连续四天对未变化药物及其ω-氧化和（ω-1）氧化产物的尿排泄量进行了定量分析。排泄率的讨论涉及酶诱导效应等方面。
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