Tang B K, Inaba T, Kalow W
Drug Metab Dispos. 1975 Nov-Dec;3(6):479-86.
After oral administration of 14C-labeled amobarbital to healthy subjects, most of the radioactivity was recovered in urine and only 4-5% in feces over a period of 6 days. No unchanged amobarbital was excreted. Two major metabolites were found and isolated. One was 3'-hydroxyamobarbital, which has been previously identified by Maynert. The second could be identified as N-hydroxyamobarbital on the basis of its spectral and chemical properties.
给健康受试者口服14C标记的异戊巴比妥后，在6天的时间里，大部分放射性物质在尿液中被回收，而在粪便中仅回收4-5%。未排出未变化的异戊巴比妥。发现并分离出两种主要代谢物。一种是3'-羟基异戊巴比妥，此前已由梅纳特鉴定出来。根据其光谱和化学性质，第二种可鉴定为N-羟基异戊巴比妥。
