Graf E
Technology Center, Tastemaker, Cincinnati, OH 45216.
Free Radic Biol Med. 1992 Oct;13(4):435-48. doi: 10.1016/0891-5849(92)90184-i.
Ferulic acid is a ubiquitous plant constituent that arises from the metabolism of phenylalanine and tyrosine. It occurs primarily in seeds and leaves both in its free form and covalently linked to lignin and other biopolymers. Due to its phenolic nucleus and an extended side chain conjugation, it readily forms a resonance stabilized phenoxy radical which accounts for its potent antioxidant potential. UV absorption by ferulic acid catalyzes stable phenoxy radical formation and thereby potentiates its ability to terminate free radical chain reactions. By virtue of effectively scavenging deleterious radicals and suppressing radiation-induced oxidative reactions, ferulic acid may serve an important antioxidant function in preserving physiological integrity of cells exposed to both air and impinging UV radiation. Similar photoprotection is afforded to skin by ferulic acid dissolved in cosmetic lotions. Its addition to foods inhibits lipid peroxidation and subsequent oxidative spoilage. By the same mechanism ferulic acid may protect against various inflammatory diseases. A number of other industrial applications are based on the antioxidant potential of ferulic acid.
阿魏酸是一种普遍存在的植物成分，它源自苯丙氨酸和酪氨酸的代谢。它主要以游离形式以及与木质素和其他生物聚合物共价连接的形式存在于种子和叶子中。由于其酚核和延长的侧链共轭结构，它很容易形成共振稳定的苯氧自由基，这就是其强大抗氧化潜力的原因。阿魏酸的紫外线吸收催化稳定苯氧自由基的形成，从而增强其终止自由基链反应的能力。通过有效清除有害自由基并抑制辐射诱导的氧化反应，阿魏酸在保护暴露于空气和紫外线辐射的细胞生理完整性方面可能发挥重要的抗氧化作用。溶解在化妆乳液中的阿魏酸能为皮肤提供类似的光保护作用。将其添加到食品中可抑制脂质过氧化及随后的氧化变质。通过相同的机制，阿魏酸可能预防各种炎症性疾病。许多其他工业应用也基于阿魏酸的抗氧化潜力。
