Terada S, Suzuki N, Uchide K, Akasofu K, Nishida E
Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, Japan.
Gynecol Obstet Invest. 1992;34(2):105-10. doi: 10.1159/000292737.
In order to study the effect of testosterone on bladder calculi and tumor formation in female rats, Wistar rats were administered testosterone for 12, 18 or 24 weeks. Testosterone was found to increase the incidence of both bladder calculi and tumors in intact, but not in oophorectomized rats. It is suggested that testosterone in combination with estrogen may contribute to hyperplasia formation, in turn leading to an increased incidence of bladder calculi and tumors.
为研究睾酮对雌性大鼠膀胱结石及肿瘤形成的影响，将睾酮给予Wistar大鼠12周、18周或24周。结果发现，睾酮可增加完整雌性大鼠膀胱结石和肿瘤的发生率，但对卵巢切除的大鼠无此作用。提示睾酮与雌激素共同作用可能导致增生形成，进而使膀胱结石和肿瘤的发生率增加。
