Bergström S
Department of Obstetrics and Gynecology, Central Hospital, Maputo, Mozambique.
Gynecol Obstet Invest. 1992;34(2):73-5. doi: 10.1159/000292729.
During a 3-year period, a total of 22 pregnant women with vulvar oedema were observed in a high-risk antenatal clinic (ANC) in Maputo. They were compared with 22 unselected normal ANC attenders, matched for age, parity, gestational length and area of living. Reported and observed genital ulcers were more prevalent in the oedema group than in the referent group. Reported and observed vaginal discharge was also significantly more common in the oedema group. Syphilis screening by VDRL was positive in 61.9% of oedema cases while positivity reached 5.0% in referents (p < 0.005). Cases found seropositive on screening were confirmed using Wassermann reaction (WR) in a reference laboratory, in which WR-positive cases underwent FTA-ABS analysis and IgM assay with solid-phase haemadsorption. IgM-positive individuals were significantly more prevalent among WR-positive oedema cases than among WR-positive referents (p < 0.05). It is concluded that among antenatal attenders in Maputo presenting with vulvar oedema, a significant proportion is associated with recent syphilis. Vulvar oedema should be considered as an important marker for seropositive syphilis during pregnancy.
在3年期间，马普托一家高危产前诊所共观察到22名患有外阴水肿的孕妇。将她们与22名未经挑选的正常产前检查就诊者进行比较，这些就诊者在年龄、产次、孕周和居住地区方面相匹配。报告的和观察到的生殖器溃疡在水肿组中比在参照组中更为普遍。报告的和观察到的阴道分泌物在水肿组中也明显更为常见。通过性病研究实验室玻片试验（VDRL）进行的梅毒筛查在61.9%的水肿病例中呈阳性，而在参照组中阳性率为5.0%（p<0.005）。筛查中血清学阳性的病例在参考实验室使用瓦氏反应（WR）进行确认，其中WR阳性的病例接受荧光螺旋体抗体吸收试验（FTA-ABS）分析和固相血吸附IgM检测。IgM阳性个体在WR阳性的水肿病例中比在WR阳性的参照病例中更为普遍（p<0.05）。得出的结论是，在马普托出现外阴水肿的产前检查就诊者中，很大一部分与近期梅毒有关。外阴水肿应被视为孕期梅毒血清学阳性的一个重要标志。
