Arnaud J P, Eloy R, Adloff M, Grenier J F
Am J Surg. 1977 Mar;133(3):338-45. doi: 10.1016/0002-9610(77)90542-6.
Six different materials (3 mesh and 3 cloth) commonly used for the repair of abdominal wall hernias were evaluated in 180 rats after implantation through musculature and peritoneum. Serial macroscopic and bacteriologic investigations were done, and bursting strength of the wound was determined in all groups at intervals with an original device. Histologic criteria were used to characterize the resistance of the wound and the tolerance of the host to the foreign material. Statistical analysis of the results demonstrated: (1) after postoperative day 15, the resistance of the wound was similar for each material tested; (2) during this early period mesh materials exhibited more resistance to bursting pressures than cloth materials; (3) the incorporation of mesh material was constant, whereas encystment or extrusion was always observed after implantation of cloth material; (4) no infection occurred with mesh material, but significant bacteria were found in 18 per cent of cloth material implantations; (5) the extent of the cellular reaction, the enumeration of giant, inflammatory, and fibroblastic cells showed the superiority of mesh materials; and (6) the ratio of fibroblasts to inflammatory cells reflected closely the mechanical resistance and tolerance of the foreign material.
通过肌肉组织和腹膜植入后，在180只大鼠中评估了常用于修复腹壁疝的六种不同材料（3种网片和3种织物）。进行了系列宏观和细菌学研究，并使用一种原始装置定期测定所有组伤口的抗破裂强度。采用组织学标准来表征伤口的抵抗力以及宿主对外来材料的耐受性。结果的统计分析表明：（1）术后第15天之后，所测试的每种材料的伤口抵抗力相似；（2）在此早期阶段，网片材料比织物材料对破裂压力表现出更大的抵抗力；（3）网片材料的融合是持续的，而在植入织物材料后总是观察到包囊形成或挤出；（4）网片材料未发生感染，但在18%的织物材料植入中发现了大量细菌；（5）细胞反应的程度、巨细胞、炎性细胞和成纤维细胞的计数显示了网片材料的优越性；（6）成纤维细胞与炎性细胞的比例密切反映了外来材料的机械抵抗力和耐受性。
