Arnaud J P, Eloy R, Aprahamian M, Adloff M, Grenier J F
Acta Chir Belg. 1977 Nov-Dec;76(6):575-82.
This experimental work is a comparative trial in the rat of 6 inert prostheses (3 permeable and 3 non-permeable) that are regularly used in man for the repair of large abdominal wall defects. This is performed in both aseptic and septic conditions. Serial macroscopic and bacteriological observations were done. Quantitative histological criteria were defined to characterize the resistance and biological tolerance to the material. This shows that: 1. the width of the cellular reaction, the number of giant, inflammatory, fibroblastic cells confirms the superiority of meshes whatever the implantation conditions; 2. the proportion of fibroblasts to inflammatory cells is a histological expression of the solidity of the repair and of the biological tolerance to the material (Acta chir. belg., 1977, 76, 575-582).
这项实验工作是在大鼠身上对6种惰性假体（3种可渗透的和3种不可渗透的）进行的对比试验，这些假体常用于人类修复大的腹壁缺损。实验在无菌和感染条件下进行。进行了系列宏观和细菌学观察。定义了定量组织学标准以表征材料的抗性和生物耐受性。结果表明：1. 无论植入条件如何，细胞反应的宽度、巨细胞、炎性细胞和成纤维细胞的数量均证实了网片的优越性；2. 成纤维细胞与炎性细胞的比例是修复稳固性和材料生物耐受性的组织学表现（《比利时外科学报》，1977年，76卷，575 - 582页）。
