Jeffreys A J, Allen M J, Hagelberg E, Sonnberg A
Department of Genetics, University of Leicester, UK.
Forensic Sci Int. 1992 Sep;56(1):65-76. doi: 10.1016/0379-0738(92)90148-p.
There has been considerable controversy over the identity of the skeletal remains exhumed in Brazil in 1985 and believed to be those of Dr Josef Mengele, the Auschwitz 'Angel of Death'. Bone DNA analysis was therefore conducted in an attempt to provide independent evidence of identity. Trace amounts of highly degraded human DNA were successfully extracted from the shaft of the femur. Despite the presence of a potent inhibitor of DNA amplification, microsatellite alleles could be reproducibly amplified from the femur DNA. Comparison of the femur DNA with DNA from Josef Mengele's son and wife revealed a bone genotype across 10 different loci fully compatible with paternity of Mengele's son. Less than 1 in 1800 Caucasian individuals unrelated to Mengele's son would by chance show full paternal inclusion. DNA analysis therefore provides very strong independent evidence that the remains exhumed from Brazil are indeed those of Josef Mengele.
1985年在巴西挖掘出的骨骼遗骸被认为是奥斯维辛“死亡天使”约瑟夫·门格勒博士的遗骨，对此一直存在很大争议。因此进行了骨骼DNA分析，试图提供独立的身份证据。从股骨骨干中成功提取出微量高度降解的人类DNA。尽管存在一种强大的DNA扩增抑制剂，但仍能从股骨DNA中可重复地扩增出微卫星等位基因。将股骨DNA与约瑟夫·门格勒儿子和妻子的DNA进行比较，发现在10个不同位点的骨骼基因型与门格勒儿子的父系完全匹配。与门格勒儿子无血缘关系的高加索人中，随机出现完全父系匹配的概率不到1/1800。因此，DNA分析提供了非常有力的独立证据，证明从巴西挖掘出的遗骸确实是约瑟夫·门格勒的。
