Leite-de-Moraes M C, Hontebeyrie-Joskowicz M, Dardenne M, Savino W
Unité d'Immunoparasitologie, Institut Pasteur, Paris, France.
Immunology. 1992 Sep;77(1):95-8.
Several observations have demonstrated the importance of T-cell-mediated mechanisms in experimental Chagas' disease. In previous studies, we have shown that mice acutely infected by Trypanosoma cruzi develop a progressive thymic atrophy with severe alterations in the lymphoid compartment. In this report we performed a kinetic analysis of the murine thymic lymphocytes comparing acute and chronic phases of infection. At the chronic phase, we observed that total thymocyte numbers returned to age-matched control values. Additionally, the decrease in the percentage of CD4+CD8+, in parallel with an increase of CD4+CD8-, CD4-CD8+, CD3high, TcR alpha beta and TcR gamma delta cells detected in the acute infection, was also restored in chronically infected mice. This thymocyte recovering is probably linked to the increase in the percentage of thymocyte precursors, such as CD4lowCD8- and CD4-CD8low cells, together with the increase in the number of IL-2R+ and cycling cells, appearing in the late stages of acute infection.
多项观察结果已证明T细胞介导机制在实验性恰加斯病中的重要性。在先前的研究中，我们已表明，被克氏锥虫急性感染的小鼠会出现进行性胸腺萎缩，且淋巴区室会发生严重改变。在本报告中，我们对小鼠胸腺淋巴细胞进行了动力学分析，比较了感染的急性期和慢性期。在慢性期，我们观察到胸腺细胞总数恢复到了与年龄匹配的对照值。此外，急性感染时检测到的CD4+CD8+百分比的降低，与CD4+CD8-、CD4-CD8+、CD3high、TcRαβ和TcRγδ细胞百分比的增加同时出现，在慢性感染小鼠中也得到了恢复。这种胸腺细胞的恢复可能与胸腺细胞前体百分比的增加有关，例如CD4lowCD8-和CD4-CD8low细胞，以及急性感染后期出现的IL-2R+细胞和循环细胞数量的增加。
