Russo M, Starobinas N, Minoprio P, Coutinho A, Hontebeyrie-Joskowicz M
Departamento de Immunologia, Universidade de Sao Paulo, Brasil.
Ann Inst Pasteur Immunol. 1988 May-Jun;139(3):225-36. doi: 10.1016/0769-2625(88)90136-5.
In order to characterize the role played by CD4+ T lymphocytes in the immunopathology of acute Trypanosoma cruzi infection, we compared the numbers of blood and tissue parasites and the heart inflammatory reaction in normal and anti-CD4 antibody-treated C3H mice. Treatment of mice with anti-CD4 mAb during acute infection markedly inhibited T-helper-cell-dependent activities, as measured by peritoneal macrophage activation and immunoglobulin secretion by splenic B lymphocytes. After in vivo inactivation of helper T cells, the number of blood and tissue parasites significantly increased, while the inflammatory cellular infiltrates of heart muscles diminished. Our results indicate that CD4+ T lymphocytes play a dual role in the immunopathology of acute experimental Chagas' disease.
为了明确CD4 + T淋巴细胞在克氏锥虫急性感染免疫病理学中所起的作用，我们比较了正常C3H小鼠和经抗CD4抗体处理的C3H小鼠血液及组织中的寄生虫数量以及心脏的炎症反应。在急性感染期间用抗CD4单克隆抗体处理小鼠，可显著抑制辅助性T细胞依赖性活动，这可通过腹膜巨噬细胞激活和脾B淋巴细胞免疫球蛋白分泌来衡量。在体内使辅助性T细胞失活后，血液和组织中的寄生虫数量显著增加，而心肌的炎性细胞浸润减少。我们的结果表明，CD4 + T淋巴细胞在急性实验性恰加斯病的免疫病理学中起双重作用。
