Stevens M G, Pugh G W, Tabatabai L B
Brucellosis Research Unit, National Animal Disease Center, Ames, Iowa 50010.
Infect Immun. 1992 Oct;60(10):4407-9. doi: 10.1128/iai.60.10.4407-4409.1992.
Increased resistance to infection with Brucella abortus 2308 resulted when recombinant murine gamma interferon (rMuIFN-gamma) was given to mice both before and during infection but not when given only before infection. Mice given rMuIFN-gamma had enhanced peritoneal and splenic macrophage bactericidal activity against B. abortus. Treatment of mice with rMuIFN-gamma plus indomethacin did not further enhance resistance to infection or macrophage bactericidal activity compared with that after treatment of mice with rMuIFN-gamma alone.
在感染布鲁氏菌2308之前及感染期间给小鼠注射重组鼠γ干扰素（rMuIFN-γ），可增强小鼠对该菌感染的抵抗力；而仅在感染前给予则无此效果。接受rMuIFN-γ的小鼠对流产布鲁氏菌的腹腔和脾脏巨噬细胞杀菌活性增强。与单独用rMuIFN-γ治疗小鼠相比，用rMuIFN-γ加吲哚美辛治疗小鼠并未进一步增强其抗感染能力或巨噬细胞杀菌活性。
