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本文引用的文献

1
Comparison of the cytokine immune response to pathogenic Yersinia enterocolitica bioserotype 1B/O:8 and 2/O:9 in susceptible BALB/C and resistant C57BL/6 mice.易感 BALB/C 小鼠和抗性 C57BL/6 小鼠对致病性肠炎耶尔森菌生物型 1B/O:8 和 2/O:9 的细胞因子免疫反应比较。
Mol Immunol. 2013 Oct;55(3-4):365-71. doi: 10.1016/j.molimm.2013.03.017. Epub 2013 Apr 10.
2
Outer membrane vesicles from Brucella abortus promote bacterial internalization by human monocytes and modulate their innate immune response.布鲁氏菌外膜囊泡促进人单核细胞内化细菌，并调节其固有免疫反应。
PLoS One. 2012;7(11):e50214. doi: 10.1371/journal.pone.0050214. Epub 2012 Nov 26.
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Host interferon-γ inducible protein contributes to Brucella survival.宿主干扰素-γ诱导蛋白有助于布鲁氏菌的存活。
Front Cell Infect Microbiol. 2012 Apr 27;2:55. doi: 10.3389/fcimb.2012.00055. eCollection 2012.
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Comparison of lipopolysaccharide and protein immunogens from pathogenic Yersinia enterocolitica bio-serotype 1B/O:8 and 2/O:9 using SDS-PAGE.应用 SDS-PAGE 比较致病性小肠结肠炎耶尔森氏菌生物血清型 1B/O:8 和 2/O:9 的脂多糖和蛋白质免疫原。
Biomed Environ Sci. 2012 Jun;25(3):282-90. doi: 10.3967/0895-3988.2012.03.005.
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Comparative antigenic proteins and proteomics of pathogenic Yersinia enterocolitica bio-serotypes 1B/O: 8 and 2/O: 9 cultured at 25°C and 37°C.25°C 和 37°C 培养的致病性肠侵袭性大肠杆菌生物血清型 1B/O:8 和 2/O:9 的比较抗原蛋白和蛋白质组学。
Microbiol Immunol. 2012 Sep;56(9):583-94. doi: 10.1111/j.1348-0421.2012.00478.x.
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Multiple-locus variable-number tandem-repeat analysis of pathogenic Yersinia enterocolitica in China.中国致病性小肠结肠炎耶尔森氏菌的多位点可变数目串联重复分析。
PLoS One. 2012;7(5):e37309. doi: 10.1371/journal.pone.0037309. Epub 2012 May 15.
7
Host susceptibility to Brucella abortus infection is more pronounced in IFN-γ knockout than IL-12/β2-microglobulin double-deficient mice.在布鲁氏菌感染中，与白细胞介素-12/β2-微球蛋白双缺陷小鼠相比，干扰素-γ基因敲除小鼠对布鲁氏菌流产亚种感染的易感性更为明显。
Clin Dev Immunol. 2012;2012:589494. doi: 10.1155/2012/589494. Epub 2011 Dec 11.
8
Potential role of fibroblast-like synoviocytes in joint damage induced by Brucella abortus infection through production and induction of matrix metalloproteinases.成纤维样滑膜细胞在布鲁氏菌感染诱导的关节损伤中的潜在作用：通过基质金属蛋白酶的产生和诱导。
Infect Immun. 2011 Sep;79(9):3619-32. doi: 10.1128/IAI.05408-11. Epub 2011 Jul 5.
9
Complete genome sequence of a Yersinia enterocolitica "Old World" (3/O:9) strain and comparison with the "New World" (1B/O:8) strain.肠侵袭型耶尔森氏菌“旧世界”（3/O:9）菌株的全基因组序列与“新世界”（1B/O:8）菌株的比较。
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10
An oral vaccine based on U-Omp19 induces protection against B. abortus mucosal challenge by inducing an adaptive IL-17 immune response in mice.基于 U-Omp19 的口服疫苗通过在小鼠中诱导适应性 IL-17 免疫应答来抵抗 B. abortus 黏膜挑战，从而诱导保护作用。
PLoS One. 2011 Jan 14;6(1):e16203. doi: 10.1371/journal.pone.0016203.

比较布鲁氏菌和小肠结肠炎耶尔森菌 O:9 型感染 BALB/c 小鼠的细胞因子免疫反应。

Comparison of cytokine immune responses to Brucella abortus and Yersinia enterocolitica serotype O:9 infections in BALB/c mice.

机构信息

National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.

出版信息

Infect Immun. 2013 Dec;81(12):4392-8. doi: 10.1128/IAI.00856-13. Epub 2013 Sep 16.

DOI:10.1128/IAI.00856-13
PMID:24042115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3837982/
Abstract

Brucella abortus and Yersinia enterocolitica serotype O:9 serologically cross-react in the immune response with the host; therefore, our aim was to compare the immune responses to these two pathogens. We selected typical B. abortus and Y. enterocolitica O:9 strains to study the cytokine immune response and the histopathological changes in livers and spleens of BALB/c mice. The data showed the cytokine responses to the two strains of pathogens were different, where the average levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), gamma interferon (IFN-γ), interleukin-12 (IL-12), and tumor necrosis factor alpha (TNF-α) were higher with B. abortus infections than with Y. enterocolitica O:9 infections, especially for IFN-γ, while the IL-10 level was lower and the levels of IL-1β, IL-4, IL-5, and IL-6 were similar. The histopathological effects in the livers and spleens of the BALB/c mice with B. abortus and Y. enterocolitica O:9 infections were similar; however, the pathological changes in the liver were greater with B. abortus infections, while damage in the spleen was greater with Y. enterocolitica O:9 infections. These observations show that different cytokine responses and histopathological changes occur with B. abortus and Y. enterocolitica O:9 infections.

摘要

布鲁氏菌和肠炎沙门氏菌 O:9 型在宿主的免疫反应中具有血清学交叉反应；因此，我们的目的是比较这两种病原体的免疫反应。我们选择了典型的布鲁氏菌和肠炎沙门氏菌 O:9 株，研究它们在 BALB/c 小鼠肝脏和脾脏中的细胞因子免疫反应和组织病理学变化。数据显示，两种病原体的细胞因子反应不同，布鲁氏菌感染的平均水平较高，而肠炎沙门氏菌 O:9 感染的平均水平较低，其中粒细胞-巨噬细胞集落刺激因子（GM-CSF）、γ干扰素（IFN-γ）、白细胞介素-12（IL-12）和肿瘤坏死因子-α（TNF-α）水平较高，尤其是 IFN-γ，而白细胞介素-10（IL-10）水平较低，白细胞介素-1β（IL-1β）、白细胞介素-4（IL-4）、白细胞介素-5（IL-5）和白细胞介素-6（IL-6）水平相似。BALB/c 小鼠肝脏和脾脏中布鲁氏菌和肠炎沙门氏菌 O:9 感染的组织病理学效应相似；然而，布鲁氏菌感染的肝脏病理变化更大，而肠炎沙门氏菌 O:9 感染的脾脏损伤更大。这些观察结果表明，布鲁氏菌和肠炎沙门氏菌 O:9 感染会引起不同的细胞因子反应和组织病理学变化。