Boorman G A, Luster M I, Dean J H, Luebke R W
J Clin Lab Immunol. 1982 Feb;7(2):119-26.
Bone marrow cellularity, hematopoietic progenitor cells and immune alterations were evaluated in mice following short term adult exposures to non-ulcerogenic levels of indomethacin. Body and organ weights showed no significant changes with the exception of the spleen where a dose dependent weight increase was noted. Bone marrow cellularity and pleuripotent hemopoietic stem cells (CFU-S) were unaltered while granulocyte-macrophage progenitors (CFU-GM) and splenic erythropoiesis were increased. Indomethacin exposure caused increased macrophage function as evidenced by enhanced phagocytosis. Lymphoproliferative response of splenocytes to T-cell mitogens was depressed while B-cell mitogenic response was not affected. These results indicate that indomethacin affects selective components of the immune and hemopoietic cells at dose levels that cause no other significant pathological alterations.
